Transthyretin (TTR)
thyroxine-binding prealbumin
Transthyretin (TTR), formerly known as thyroxine-binding prealbumin, is a tetrameric protein transporting hormones in the plasma and brain. It forms a complex with retinol-binding protein (RBP), which facilitates the transport of thyroid hormones and vitamin A in the blood and cerebrospinal fluid. TTR is a positive indicator of nutrition status and is negatively correlated with inflammation. TTR is a neuroprotective and oxidative-stress-suppressing factor. The TTR structure is destabilized by mutations, oxidative modifications, aging, proteolysis, and metal cations, including Ca2+. Destabilized TTR molecules form amyloid deposits, resulting in senile and familial amyloidopathies.
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Transthyretin (TTR) Related Products (42)
Related Products (42)
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Antibodies (3)
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Tafamidis meglumine (Standard)
0 ImagesSynonyms: Fx-1006A (Standard)Tafamidis meglumine (Standard) is the analytical standard of Tafamidis meglumine. This product is intended for research and analytical applications. Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis.
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TTR stabilizer L6
0 ImagesCat. No.: HY-126927CAS No.: 881290-53-5TTR stabilizer L6 (L6) binds to the T4 binding pocket of transthyretin (TTR), which can prevent the dissociation of TTR to monomer. TTR stabilizer L6 is promising for research of familial amyloid polyneuropathy.
